OBJECTIVES: To investigate the association of serum albumin (SA) with oxidative damage of human atherosclerotic plaques and the severity of atherosclerosis. DESIGN AND METHODS: Correlation of the levels of SA with those of lipid and protein oxidation of endarterectomy-removed carotid atherosclerotic plaques; SA and plaque oxidative biomarkers comparison between 2 groups of patients with different severity of atherosclerotic carotid stenosis, i.e. <90% (group I) or ≥90% (group II). RESULTS: SA was strongly inversely correlated with plaque oxidative damage; SA was lower and plaque oxidative damage higher in group II than group I. CONCLUSIONS: Lowered SA is associated with oxidative damage of atherosclerotic plaques and the severity of atherosclerosis.

Serum albumin and biomolecular oxidative damage of human atherosclerotic plaques

CUCCURULLO, Chiara;
2010

Abstract

OBJECTIVES: To investigate the association of serum albumin (SA) with oxidative damage of human atherosclerotic plaques and the severity of atherosclerosis. DESIGN AND METHODS: Correlation of the levels of SA with those of lipid and protein oxidation of endarterectomy-removed carotid atherosclerotic plaques; SA and plaque oxidative biomarkers comparison between 2 groups of patients with different severity of atherosclerotic carotid stenosis, i.e. <90% (group I) or ≥90% (group II). RESULTS: SA was strongly inversely correlated with plaque oxidative damage; SA was lower and plaque oxidative damage higher in group II than group I. CONCLUSIONS: Lowered SA is associated with oxidative damage of atherosclerotic plaques and the severity of atherosclerosis.
http://www.ncbi.nlm.nih.gov/pubmed/20807525
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11695/4394
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