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Pleiotropic Actions of Gastrodia Elata Glucosides in the Treatment of Painful Neuropathies and CNS Disorders: Focus on Mitochondrial Dysfunction and Modulation of Ion Channels

Glycosides contained in Gastrodia elata have consistently shown neuroprotective and anti-inflammatory activity in preclinical models of neurological disorders, including peripheral neuropathies, cerebrovascular disorders, and chronic neurodegenerative disorders. In a commercial product used in Italy, gastrodin has replaced α-lipoic, the use of which is now limited by unexpected adverse effects, such as severe hypoglycemia. The clinical efficacy of gastrodin in traditional Chinese medicine has...

Metrological comparison of fiber-optic and conventional spectrophotometry for visible spectra of liquid dye solutions

This study evaluates the consistency between optical fiber Spectroscopy and conventional spectrophotometry for three representative dyes — Fluorescein, Methylene Blue, and Nile Red — measured in both polystyrene and quartz cuvettes. For the non-fluorescent dyes, Methylene Blue and Nile Red, optical fiber and spectrophotometry produce fully consistent spectra across all concentrations and in both materials, with scaling factors close to unity and negligible offsets, confirming that non-emissiv...

The Role of Phytochemicals in Aging and Aging-Related Diseases

: Over the past century, advances in medical care, hygiene, and nutrition have greatly extended human lifespan [...].

Poteri cautelari degli arbitri e sequestro conservativo di nave o di carati: la novità legislativa al "banco di prova" del diritto della navigazione (Parte I)

The new text of the art. 818 c.p.c., introduced by the «Cartabia» reform, allows the parties to give arbitrators the power to grant precautionary measures. The legislative innovation gives rise to doubts and determines coordination problems both with respect to the precautionary power generally attributed to the competence of the ordinary judge and in relation to the overall regulatory framework in which it fits. Particular and complex questions arise in the case in which the precaution...

Feeding difficulties, eating disorders and therapeutic approaches in autism spectrum disorder: An overview

Feeding problems are highly prevalent in individuals with autism spectrum disorder (ASD) from early developmental stages. Difficulties during the transition to solid foods, limited dietary variety, and reluctance to try new foods since infancy, combined with gastrointestinal disorders, represent significant concerns for both parents and clinicians from diagnostic and, more importantly, therapeutic perspectives. The primary clinical link between atypical eating behaviors and core autistic symp...

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