Alterations of the cytoskeleton are commonly associated with tumor genesis and cancer progression. For this reason, the characterization of cytoskeleton-associated functions and properties is important to optimize the outcomes to classical and more recent therapeutic approaches, such as chemotherapy, radiotherapy and cancer nanomedicine. In such context, this work investigated the synergy between cancer nanomedicine and radiotherapy. In particular, the effects over time (24 and 48 h) of two different doses of X-rays (2 and 10 Gy) on spreading area, morphological parameters and the internalization mechanism of carboxylated nanoparticles in mammary epithelial cells and mammary adenocarcinoma cells were investigated.
X-rays affect cytoskeleton assembly and nanoparticle uptake: Preliminary results
Fusco S.
Ultimo
2018-01-01
Abstract
Alterations of the cytoskeleton are commonly associated with tumor genesis and cancer progression. For this reason, the characterization of cytoskeleton-associated functions and properties is important to optimize the outcomes to classical and more recent therapeutic approaches, such as chemotherapy, radiotherapy and cancer nanomedicine. In such context, this work investigated the synergy between cancer nanomedicine and radiotherapy. In particular, the effects over time (24 and 48 h) of two different doses of X-rays (2 and 10 Gy) on spreading area, morphological parameters and the internalization mechanism of carboxylated nanoparticles in mammary epithelial cells and mammary adenocarcinoma cells were investigated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
