Analysis of UV-visible spectra, performed on commercial riboflavin-based eye drops, showed that absorbance is a saturating function of vitamin concentration. This implies a threshold concentration, Ct, such that for riboflavin concentration > Ct the absorbance remains constant and the effectiveness of the eye drops is independent of the dose used. These experimental results were combined with a diffusion-reaction model to elucidate the mechanism of action within the cornea. The model predicts that the eye drops have a low effectiveness on UVB and UVC, while they have a good performance for UVA. Indeed, at the center of the cornea the transmittance is significantly reduced and after 1 h it is reduced by about 70% compared to a cornea devoid of eye drops.
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1039/d0ra00417k|
|Codice identificativo ISI:||WOS:000528740900059|
|Codice identificativo Scopus:||2-s2.0-85083590354|
|Titolo:||Reaction-diffusion model as framework for understanding the role of riboflavin in "eye defence" formulations|
|Appare nelle tipologie:||1.1 Articolo in rivista|