Correlation between thyroid endocrine status, change in body weight & macular thickness in obese patients

Objective: Study the co-relationship between thyroid status, obesity and macular thickness (MT) since from ophthalmic point of view, regulation of the aqueous-lipid balance resulted altered. Methods: Obese patients (40), 20 males and 20 females, aging between 30-50 years have been enrolled in this study. All patients underwent to both biochemical and OTC evaluation. Results: After a low-calorie diet, low fat and low salt, a remarkable weight change; weight fat mass (-17%), lean body mass (+9.0%), BMI (-13%) and body weight (-13%) were achieved. All blood parameters significantly lowered: uric acid (-45%), bilirubin (-46%), total cholesterol (-25%), HDL (+63%), LDL (-17%), triglycerides (-37%), and circulating glucose (-13%). A significative reduction of FT3, FT4 and TSH has also been observed. The reduction of the MT was also significant (-7.5%). Significant correlations between the MT detected pre- and post-treatment and lean mass (p<0.005), BMI post-treatment (p<0.011), BMI reduction (p<0.022) and body weight reduction (p<0.027). Finally, the same significant correlations are also present between the MT detected post-treatment and posttreatment lean mass (p<0.007), post-treatment BMI (p<0.007), BMI reduction (p<0.045) and body weight reduction (p<0.042). Conclusions: There is a correlation between body and blood parameters variations, thyroid endocrine status and MT changes in obese patients undergone hypo caloric diet.