To determine whether differences in LDLr behavior in extra-hepatic tissues and whether extra-hepatic receptors could differentially contribute to cholesterol homeostasis under physiological conditions, we evaluated the presence and regulation of LDLr from both a gender and an aging perspective. We used the brain cortex, the gastrocnemius, and the heart ventricle of 3- and 12-month-old male and female rats. We observed a protein decrease of total LDLr in 12-month-old female rat brains that was completely restored by 17-β estradiol treatment. In the gastrocnemius, LDLr accumulates in the skeletal muscle in both male and female aged rats as a precursor probably due to a glycosylation impairment. In the heart, no modifications were observed in either older rats or rats of a specific gender. These data highlight a tissue-specific dysregulation of LDLr that is age- and gender-dependent.
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jcp.22607|
|Codice identificativo ISI:||WOS:000294214400018|
|Codice identificativo Scopus:||2-s2.0-79960693880|
|Titolo:||Age- and sex-related differences in extra-hepatic low-density lipoprotein receptor|
|Appare nelle tipologie:||1.1 Articolo in rivista|