The aim of the present research is to explain why well-being in the workplace is a theme of increasing interest and why many studies have analyzed its functioning and diffusion. From the literature on well-being it is evident that the findings of previous research are sometimes discordant and theoretical models particularly use diverse variables according to different needs and objectives. Despite the influence of a number of different factors, well-being can be studied by looking at three main aspects: physical well-being, mental health, and job satisfaction. The variables influencing it, however, are numerous and often analyzed from different perspectives. Methods of analysis vary across national and disciplinary contexts. The present work is based on a local survey of a small Italian district that investigates two hypotheses about the correlation between locus of control and variables determining work well-being (Spector et al., 2002) and the possibility of using perceptions and desires on the variables influencing well-being as predictors of it. We use the concepts of cybernetic theory and feedback loop (Edwards, 1992). Findings of statistical correlation and hierarchic regression are discussed; limitations and suggestions for further research are presented.