Traditional risk factors of cardiovascular death in the general population, including body mass index (BMI), serum cholesterol, and blood pressure are also found to relate to outcomes in the geriatric population, but in a differing direction. A higher body mass index, hypercholesterolemia and hypertension are not harmful but even permit better survival at advancing age. This phenomenon is called âreverse epidemiologyâ or ârisk factor paradoxâ and is also detected in a variety of chronic disease states such as chronic heart failure. Accordingly, a low BMI, blood pressure and cholesterol values are associated with a worse prognosis. Several possible causes are hypothesized to explain this elderly paradox, but this phenomenon remains controversial and its underlying reasons are poorly understood. The aim of this review is to recognize the factors behind this intriguing phenomenon and analyse the consequences that it can bring in the management of the cardiovascular therapy in elderly patient. Finally, a new phenotype identified as âcatabolic syndromeâ has been postulated.
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s40520-017-0815-7|
|Codice identificativo ISI:||WOS:000433140500001|
|Codice identificativo Scopus:||2-s2.0-85027151778|
|Titolo:||The reverse metabolic syndrome in the elderly: Is it a âcatabolicâ syndrome?|
|Appare nelle tipologie:||1.1 Articolo in rivista|