Particle size-number distributions of aerosol from e-cigarettes (0 and 14 mg mLâ1 nicotine) were compared with conventional cigarettes. Results were used to provide age-specific (9â21 years) dosimetry estimates applying the MMPD model. After a 2-s puff, total number doses (DTot) were highest for 9 years of age (6.01 Ã 1010â1.31 Ã 1011 particles) and lowest for 18 years of age (4.69 Ã 1010â1.06 Ã 1011 particles). Such doses represented about 19â45 and 25â100% of the relevant daily doses of not smoking individuals, respectively, in tracheobronchial (TB) and alveolar (A) regions. DTot for the e-cigarettes were about double that for conventional cigarette. Deposition densities and daily volume of e-cigarette liquid deposited per unit surface area were maximum at lobar bronchi, highest for 9 years and lowest for 21 years age.
Electronic cigarettes: age-specific generation-resolved pulmonary doses
Avino, Pasquale
2017-01-01
Abstract
Particle size-number distributions of aerosol from e-cigarettes (0 and 14 mg mLâ1 nicotine) were compared with conventional cigarettes. Results were used to provide age-specific (9â21 years) dosimetry estimates applying the MMPD model. After a 2-s puff, total number doses (DTot) were highest for 9 years of age (6.01 Ã 1010â1.31 Ã 1011 particles) and lowest for 18 years of age (4.69 Ã 1010â1.06 Ã 1011 particles). Such doses represented about 19â45 and 25â100% of the relevant daily doses of not smoking individuals, respectively, in tracheobronchial (TB) and alveolar (A) regions. DTot for the e-cigarettes were about double that for conventional cigarette. Deposition densities and daily volume of e-cigarette liquid deposited per unit surface area were maximum at lobar bronchi, highest for 9 years and lowest for 21 years age.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.