Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting apocrine gland-rich areas of the body and presenting with painful nodules, abscesses, sinus tracts, and scarring. HS is a multifactorial disease in which genetic and environmental factors play a key role. The primary defect in HS pathophysiology involves follicular occlusion of the folliculopilosebaceous unit, followed by follicular rupture, and immune responses (perifollicular lympho-histiocytic inflammation), finally leading to the development of clinical HS lesions. HS has a destructive impact on the patientâs quality of life, being a very challenging disease. Available treatments are limited, mostly off-label and with high variability in the reported efficacy. Fortunately, a monoclonal antibody against tumor necrosis factor alpha has been recently approved for treatment of moderate to severe HS, offering patients a promising new option. This review focuses on the main features of HS, including epidemiology, clinical aspects, pathogenesis, severity classifications, comorbidities, and currently available treatments.
|Digital Object Identifier (DOI):||http://dx.doi.org/10.2147/CCID.S111019|
|Codice identificativo ISI:||WOS:000399480300001|
|Codice identificativo Scopus:||2-s2.0-85020509551|
|Titolo:||Hidradenitis suppurativa: From pathogenesis to diagnosis and treatment|
|Appare nelle tipologie:||1.1 Articolo in rivista|