Healthy ageing involves the interaction between genes, the environment, and lifestyle factors, particularly diet. Diet-regulated genes play a crucial role in the onset and progression of several chronic disorders including skin diseases and dietary interventions can be used to mitigate these diseases but also to maintain health. The nutrient regulation of key genes involved in ageing may prevent oxidation and inflammation, reducing cellular damages to proteins, membranes, and mitochondria. In recent years there has been a growing interest, supported by a large number of experimental and epidemiological studies, about the beneficial effects of some commonly used food-derived products, including macro-and micronutrients and dietary phytochemicals. In particular, fruits, spices and herbs often contain active phenolic substances endowed with potent antioxidant and chemo-preventive properties. Among polyphenols, anthocyanins, a subfamily belonging to the flavonoid group, have shown to modulate a variety of biochemical/signalling pathways involved in promoting organism physiology and general health status, including vasculo-protective effects, cognitive process enhancement, anti-cancer activity and skin photo-protection. Among the anthocyanin species, delphinidin [2-(3,4,5-trihydroxyphenyl) chromenylium-3,5,7-triol] represent the most potent antioxidant. The richest known natural source of delphinidin is the maqui berry (Aristotelia chilensis), a super-fruit indigenous to Chile. We have recently performed a randomized double-blind nutritional trial, and demonstrated the in vivo ability of maqui polyphenols to protect lipids from oxidative damages. This and other studies have begun to provide a basis for considering the use of maqui and delphinidin in the development of novel nutritional interventional strategies for health management and against specific age-associated diseases. In this review we will provide an overview of the current literature emphasizing antioxidant and anti-inflammatory pathways modulated by maqui berry and its polyphenolic components, mostly delphinidin. Moreover, we will focus on experimental studies showing that delphinidin of maqui may have a positive impact on skin health.
Maqui (Aristotelia chilensis) berry and its major polyphenol delphinidin: Relevance for skin photo-protection and anti-aging.
SCAPAGNINI, Giovanni;DAVINELLI, SERGIO
2016-01-01
Abstract
Healthy ageing involves the interaction between genes, the environment, and lifestyle factors, particularly diet. Diet-regulated genes play a crucial role in the onset and progression of several chronic disorders including skin diseases and dietary interventions can be used to mitigate these diseases but also to maintain health. The nutrient regulation of key genes involved in ageing may prevent oxidation and inflammation, reducing cellular damages to proteins, membranes, and mitochondria. In recent years there has been a growing interest, supported by a large number of experimental and epidemiological studies, about the beneficial effects of some commonly used food-derived products, including macro-and micronutrients and dietary phytochemicals. In particular, fruits, spices and herbs often contain active phenolic substances endowed with potent antioxidant and chemo-preventive properties. Among polyphenols, anthocyanins, a subfamily belonging to the flavonoid group, have shown to modulate a variety of biochemical/signalling pathways involved in promoting organism physiology and general health status, including vasculo-protective effects, cognitive process enhancement, anti-cancer activity and skin photo-protection. Among the anthocyanin species, delphinidin [2-(3,4,5-trihydroxyphenyl) chromenylium-3,5,7-triol] represent the most potent antioxidant. The richest known natural source of delphinidin is the maqui berry (Aristotelia chilensis), a super-fruit indigenous to Chile. We have recently performed a randomized double-blind nutritional trial, and demonstrated the in vivo ability of maqui polyphenols to protect lipids from oxidative damages. This and other studies have begun to provide a basis for considering the use of maqui and delphinidin in the development of novel nutritional interventional strategies for health management and against specific age-associated diseases. In this review we will provide an overview of the current literature emphasizing antioxidant and anti-inflammatory pathways modulated by maqui berry and its polyphenolic components, mostly delphinidin. Moreover, we will focus on experimental studies showing that delphinidin of maqui may have a positive impact on skin health.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
