Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up-or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s10534-014-9742-7|
|Codice identificativo ISI:||WOS:000341783100002|
|Codice identificativo Scopus:||2-s2.0-84924527515|
|Titolo:||Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages|
|Appare nelle tipologie:||1.1 Articolo in rivista|