Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up-or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.

Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages

CUTONE, Antimo;MUSCI, Giovanni;
2014

Abstract

Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up-or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.
www.wkap.nl/journalhome.htm/0966-0844
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11695/51481
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