Defining reference values of trace elements in the tear film: Diagnostic methods  and possible applications

Semeraro, F; Costagliola, Ciro; Cancarini, A; Gilberti, E; Tosco, E; Apostoli, P.

doi:10.1016/j.ecoenv.2012.02.021

The study has been performed on tears of apparently healthy subjects who live and work in urban and rural areas, respectively. After the collection the following elements were investigated: chromium (Cr); arsenic (As); copper (Cu); zinc (Zn); selenium (Se); rubidium (Rb); barium (Ba); lead (Pb) and cobalt (Co). Significantly higher values of As were found in subjects living and working in rural areas as compared to those found in urban area residents (0.290 vs. 0.025; p<0.001). Conversely, Ba and Pb were significantly lower in rural area residents (1.10 vs. 2.50, p=0.027 and 1.70 vs. 1.10, p=0.057, respectively). Our data show that trace elements analysis in tears is possible; further studies could define if it could be a reliable biomarker in persons exposed to high concentration of trace elements due to working or environmental reasons.

Digital Object Identifier (DOI):	http://dx.doi.org/10.1016/j.ecoenv.2012.02.021
Codice identificativo ISI:	WOS:000304337300027
Codice identificativo Scopus:	2-s2.0-84860528314
Handle:	http://hdl.handle.net/11695/4733
Abstract:	The study has been performed on tears of apparently healthy subjects who live and work in urban and rural areas, respectively. After the collection the following elements were investigated: chromium (Cr); arsenic (As); copper (Cu); zinc (Zn); selenium (Se); rubidium (Rb); barium (Ba); lead (Pb) and cobalt (Co). Significantly higher values of As were found in subjects living and working in rural areas as compared to those found in urban area residents (0.290 vs. 0.025; p<0.001). Conversely, Ba and Pb were significantly lower in rural area residents (1.10 vs. 2.50, p=0.027 and 1.70 vs. 1.10, p=0.057, respectively). Our data show that trace elements analysis in tears is possible; further studies could define if it could be a reliable biomarker in persons exposed to high concentration of trace elements due to working or environmental reasons.
Titolo:	Defining reference values of trace elements in the tear film: Diagnostic methods and possible applications
Autori:	Semeraro F COSTAGLIOLA, Ciro Cancarini A Gilberti E Tosco E Apostoli P. mostra contributor esterni nascondi contributor esterni
Appare nelle tipologie:	1.1 Articolo in rivista

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