Objective: The aim of the study was to evaluate whether vitamin D[25-(OH) D(3)] status affects serum IGF-I concentrations in healthy subjects. Design and patients: Two hundred and forty-one consecutive healthy subjects were included in the present study. Measurements: Serum IGF-I and 25-(OH) D(3) concentrations. Results: As expected, serum IGF-I concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF-I levels. A positive relationship was identified between serum 25-(OH) D(3) and IGF-I concentrations (r=0.33, p<0.0001); the 25-(OH) D(3)-dependent changes of serum IGF-I concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D(3) deficiency (<20 ng/ml) had lower (185 +/- 83 mu g/l) IGF-I values than those with mild-to absent 25-(OH) D(3) deficit (225 83 mu g/l, p=0.0004). Conclusions: 25-(OH) D(3) status may contribute to determine serum IGF-I levels in healthy population. (J. Endocrinol. Invest. 34: e200-e203, 2011) (C) 2011, Editrice Kurtis

Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects

GASPERI, Maurizio;
2011-01-01

Abstract

Objective: The aim of the study was to evaluate whether vitamin D[25-(OH) D(3)] status affects serum IGF-I concentrations in healthy subjects. Design and patients: Two hundred and forty-one consecutive healthy subjects were included in the present study. Measurements: Serum IGF-I and 25-(OH) D(3) concentrations. Results: As expected, serum IGF-I concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF-I levels. A positive relationship was identified between serum 25-(OH) D(3) and IGF-I concentrations (r=0.33, p<0.0001); the 25-(OH) D(3)-dependent changes of serum IGF-I concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D(3) deficiency (<20 ng/ml) had lower (185 +/- 83 mu g/l) IGF-I values than those with mild-to absent 25-(OH) D(3) deficit (225 83 mu g/l, p=0.0004). Conclusions: 25-(OH) D(3) status may contribute to determine serum IGF-I levels in healthy population. (J. Endocrinol. Invest. 34: e200-e203, 2011) (C) 2011, Editrice Kurtis
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11695/3989
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 49
  • ???jsp.display-item.citation.isi??? 110
social impact