Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.
|Digital Object Identifier (DOI):||10.1128/AAC.45.5.1591-1594.2001|
|Codice identificativo ISI:||000168240300048|
|Codice identificativo Scopus:||2-s2.0-0035038580|
|Appare nelle tipologie:||1.1 Articolo in rivista|