Investigation of nitrated FNG as an oxidative risk marker of VTE in a large clinical trial may be warranted, also for testing the link between inflammation, oxidative/nitrative stress and VTE, but such a trial has not been undertaken yet; (2) the determination of tyrosine nitration in FNG, alongside FNG concentration, may uncover posttranslational FNG modifications that could pave the way for VTE, but could be overlooked by quantitative FNG assays; and (3) given the reported effects of FNG nitration, such as increased fibrin cross-linking by factor XIII and delayed clot lysis by plasmin, the assay of nitrated FNG may be a predictor of incomplete responses to fibrinolytic therapies.
Is it time for nitrated fibrinogen to prove its worth as a risk marker for venous thromboembolism?
Arcaro, AlessiaCo-primo
Writing – Original Draft Preparation
;Lepore, AlessioCo-primo
Writing – Original Draft Preparation
;Davinelli, Sergio;Scapagnini, Giovanni;Gentile, Fabrizio
Ultimo
Writing – Review & Editing
2025-01-01
Abstract
Investigation of nitrated FNG as an oxidative risk marker of VTE in a large clinical trial may be warranted, also for testing the link between inflammation, oxidative/nitrative stress and VTE, but such a trial has not been undertaken yet; (2) the determination of tyrosine nitration in FNG, alongside FNG concentration, may uncover posttranslational FNG modifications that could pave the way for VTE, but could be overlooked by quantitative FNG assays; and (3) given the reported effects of FNG nitration, such as increased fibrin cross-linking by factor XIII and delayed clot lysis by plasmin, the assay of nitrated FNG may be a predictor of incomplete responses to fibrinolytic therapies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
