Scleromyxedema (SM) is an uncommon disease with mucin deposition and fibroblast proliferation in the upper dermis. SM is a clinical variant of lichen myxedematosus and is characterized by a diffuse sclerodemic-like induration of the skin in addition to a peculiar lichenoid papular eruption. Usually, SM has a chronic and progressive course, sometimes with systemic involvement. In most cases the response to treatment is poor. A case of a 50-year old woman with cutaneous SM in association with esophageal aperistalsis, myopathy, and mild cardio-pulmonary involvement is reported. Seric CPK was elevated. Treatment with prednisone and cyclophosphamide led to an improvement of cutaneous and muscular symptomatology.
Scleromyxedema: A case report
Patruno C.;
1996-01-01
Abstract
Scleromyxedema (SM) is an uncommon disease with mucin deposition and fibroblast proliferation in the upper dermis. SM is a clinical variant of lichen myxedematosus and is characterized by a diffuse sclerodemic-like induration of the skin in addition to a peculiar lichenoid papular eruption. Usually, SM has a chronic and progressive course, sometimes with systemic involvement. In most cases the response to treatment is poor. A case of a 50-year old woman with cutaneous SM in association with esophageal aperistalsis, myopathy, and mild cardio-pulmonary involvement is reported. Seric CPK was elevated. Treatment with prednisone and cyclophosphamide led to an improvement of cutaneous and muscular symptomatology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
