In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.
|Digital Object Identifier (DOI):||10.1016/j.psychres.2014.08.022|
|Codice identificativo ISI:||WOS:000347361300063|
|Codice identificativo Scopus:||2-s2.0-84919627171|
|Appare nelle tipologie:||1.1 Articolo in rivista|