Introduction Minimal disease activity (MDA) is a validated outcome measure in psoriatic arthritis (PsA) defining a low disease activity state with a cutoff of 5/7. The main aim of the study was to look at the MDA divided into in the seven cutoffs, analyzing the more frequently achieved domains. The relationship between MDA, PASS, PsAID, DAPSA, and the PhGA in all cutoffs was also evaluated. Methods Cross-sectional analysis on PsA patients satisfying CASPAR criteria. An assessment of disease activity, treatment target, function, and impact of disease was performed. Patients achieving MDA were compared to patients not achieving MDA in order to evaluate the most frequent domain found. Results Ninety-three PsA patients were enrolled. MDA was satisfied in 44/93, while in 47 MDA ranged from 1/7 to 4/7. Among the seven domains, Leeds Enthesitis Index (LEI) was the most frequent domain found in all patients. In those not in MDA, BSA <= 3 (70%) and swollen joints count <= 1 (68%) were also well represented. The domains with a lower percentage of patients not in MDA were HAQ-DI <= 0.5 (38.8%), tender joint count <= 1 (23%), PtGA <= 20 (4.2%) and VAS pain <= 15 mm (2%). There was a growing trend, from MDA 1/7 to MDA 7/7 in the percentage of patients in PASS yes, in PsAID <= 4, and in DAPSA <= 14. Conclusions The present study detailed the domains more achieved also in those patients not in MDA showing that "physician-driven" domains are more frequently achieved in our patients.

The "Climb" Towards Minimal Disease Activity in Psoriatic Arthritis

Lubrano, Ennio;Scriffignano, Silvia;Perrotta, Fabio Massimo
Ultimo
2021-01-01

Abstract

Introduction Minimal disease activity (MDA) is a validated outcome measure in psoriatic arthritis (PsA) defining a low disease activity state with a cutoff of 5/7. The main aim of the study was to look at the MDA divided into in the seven cutoffs, analyzing the more frequently achieved domains. The relationship between MDA, PASS, PsAID, DAPSA, and the PhGA in all cutoffs was also evaluated. Methods Cross-sectional analysis on PsA patients satisfying CASPAR criteria. An assessment of disease activity, treatment target, function, and impact of disease was performed. Patients achieving MDA were compared to patients not achieving MDA in order to evaluate the most frequent domain found. Results Ninety-three PsA patients were enrolled. MDA was satisfied in 44/93, while in 47 MDA ranged from 1/7 to 4/7. Among the seven domains, Leeds Enthesitis Index (LEI) was the most frequent domain found in all patients. In those not in MDA, BSA <= 3 (70%) and swollen joints count <= 1 (68%) were also well represented. The domains with a lower percentage of patients not in MDA were HAQ-DI <= 0.5 (38.8%), tender joint count <= 1 (23%), PtGA <= 20 (4.2%) and VAS pain <= 15 mm (2%). There was a growing trend, from MDA 1/7 to MDA 7/7 in the percentage of patients in PASS yes, in PsAID <= 4, and in DAPSA <= 14. Conclusions The present study detailed the domains more achieved also in those patients not in MDA showing that "physician-driven" domains are more frequently achieved in our patients.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380617/
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11695/113920
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