In recent years nanoscience have profoundly changed the medicine, both in the diagnostic field and therapeutic. It 'gave rise to nanomedicine as a discipline capable of creating personalized therapies. This new paradigm of medicine is low on the awareness of creating nanometer sized devices containing specific active principles capable of interacting with particular tissues and thus to treat particular pathologies. This discipline also provides a valuable aid in the diagnostic field with the creation of specific fluorescent systems, for example. The most effective contribution of nanomedicine is to be found in theranostics (more therapeutic diagnostics) where they build nanodevices capable of transmitting simultaneously for therapeutic use medication and diagnostic use nanoparticles. The activity of this PhD has been directed toward the creation of nano systems that have an immediate application to medicine. To achieve this goal they have developed only liposomes for water-soluble therapeutic agents. In particular they were developed special liposomal eye drops for the therapy of intraocular hypertension and liposomal solutions of vital dyes to be used in operations of canalostomia and canaloplasty liposomal solutions capable of activating the Ca2 + channel in the case of particular brain pathologies. In addition, we have been derivatized gold nanoparticles for the delivery of active ingredients through oral administration.
In questi ultimi anni le nanoscienze hanno profondamente modificato la medicina, sia in campo diagnostico sia terapeutico. E’ nata così la nanomedicina come disciplina in grado di creare terapie personalizzate. Questo nuovo paradigma della medicina si bassa sulla consapevolezza di creare dei dispositivi di dimensioni nanometriche contenenti specifici principi attivi capaci di interagire con particolari tessuti e quindi di curare particolari patologie. Tale disciplina fornisce un valido aiuto anche in campo diagnostico con la creazione di specifici sistemi fluorescenti, per esempio. Il contributo più efficace della nanomedicina è da ricercare nella teranostica (terapeutica più diagnostica) dove si costruiscono nanodevice in grado di veicolare contemporaneamente farmaci ad uso terapeutico e nanoparticelle ad uso diagnostico. L’attività di questo dottorato si è indirizzata verso la creazione di nano sistemi che avessero una immediata applicazione alla medicina. A tal prosposito si sono messi a punto solo liposomi per la veicolazioni di principi attivi idrosolubili. In particolare sono stati messi a punto particolari colliri liposomiali per la terapia dell’ipertensione intraoculare e soluzioni liposomiali di coloranti vitali da usare nelle operazioni di canalostomia e canaloplastica soluzioni liposomiali capaci di attivare il canale del Ca2+ nel caso di particolari patologie cerebrali. Inoltre sono state derivatizzate nanoparticelle colloidali di oro per la veicolazione di principi attivi attravesro la somministrazione orale.
Setup of nanodevices and their applications
DI NEZZA, Francesca
2017-04-07
Abstract
In recent years nanoscience have profoundly changed the medicine, both in the diagnostic field and therapeutic. It 'gave rise to nanomedicine as a discipline capable of creating personalized therapies. This new paradigm of medicine is low on the awareness of creating nanometer sized devices containing specific active principles capable of interacting with particular tissues and thus to treat particular pathologies. This discipline also provides a valuable aid in the diagnostic field with the creation of specific fluorescent systems, for example. The most effective contribution of nanomedicine is to be found in theranostics (more therapeutic diagnostics) where they build nanodevices capable of transmitting simultaneously for therapeutic use medication and diagnostic use nanoparticles. The activity of this PhD has been directed toward the creation of nano systems that have an immediate application to medicine. To achieve this goal they have developed only liposomes for water-soluble therapeutic agents. In particular they were developed special liposomal eye drops for the therapy of intraocular hypertension and liposomal solutions of vital dyes to be used in operations of canalostomia and canaloplasty liposomal solutions capable of activating the Ca2 + channel in the case of particular brain pathologies. In addition, we have been derivatized gold nanoparticles for the delivery of active ingredients through oral administration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.