Ageing is a challenge for any living organism and human longevity is a . complex phenotype. With increasing life expectancy, maintaining long-term health,. functionality and well-being during ageing has become an essential goal. To. increase our understanding of how ageing works, it may be advantageous to analyze. the phenotype of centenarians, perhaps one of the best examples of successful. ageing. Healthy ageing involves the interaction between genes, the environment,. and lifestyle factors, particularly diet. Besides evaluating specific. gene-environment interactions in relation to exceptional longevity, it is. important to focus attention on modifiable lifestyle factors such as diet and. nutrition to achieve extension of health span. Furthermore, a better. understanding of human longevity may assist in the design of strategies to extend. the duration of optimal human health. In this article we briefly discuss relevant. topics on ageing and longevity with particular focus on dietary patterns of. centenarians and nutrient-sensing pathways that have a pivotal role in the. regulation of life span. Finally, we also discuss the potential role of Nrf2. system in the pro-ageing signaling emphasizing its phytohormetic activation."

Extending healthy ageing: nutrient sensitive pathway and centenarian population

DAVINELLI , SERGIO;SCAPAGNINI, Giovanni
2012-01-01

Abstract

Ageing is a challenge for any living organism and human longevity is a . complex phenotype. With increasing life expectancy, maintaining long-term health,. functionality and well-being during ageing has become an essential goal. To. increase our understanding of how ageing works, it may be advantageous to analyze. the phenotype of centenarians, perhaps one of the best examples of successful. ageing. Healthy ageing involves the interaction between genes, the environment,. and lifestyle factors, particularly diet. Besides evaluating specific. gene-environment interactions in relation to exceptional longevity, it is. important to focus attention on modifiable lifestyle factors such as diet and. nutrition to achieve extension of health span. Furthermore, a better. understanding of human longevity may assist in the design of strategies to extend. the duration of optimal human health. In this article we briefly discuss relevant. topics on ageing and longevity with particular focus on dietary patterns of. centenarians and nutrient-sensing pathways that have a pivotal role in the. regulation of life span. Finally, we also discuss the potential role of Nrf2. system in the pro-ageing signaling emphasizing its phytohormetic activation."
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11695/45860
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