Nitric oxide (NO) is synthesizefdr om L-arsinine by a family of NO synthase( NOS) irofor.i. -Constitutivelye xpresseNd OS isoformse, ndothelial NOS (eNOS) and neuronal NOS (nNOS), are likely the major contributors ro whole-bodf NO production. Many studies have strongly associated polymorphismso f the eNOS gene. it"h irr..""s"d risk of hypertensionc, ardiovasculadr isease, coronary spastic angina, myocardial infarction, and stroke, but the results are not always con.l.,sirre (l73ng and !7ang 2000). In parricular,V orni-ro et al. (1998) identified a Glu)9gAsp varianr i., 1"o., 7 of the eNOS gene that was more frequent in patientsw ith coronarys pasmb, ut in studieso f an etoerlyp opulationi n Australia,L iyou et al. (199g) could find no associariono f this variant with coronarya rteryd iseaseR. ecently,v ariouse NOS polymorphismsh ave beenr eportedt o be associated with type 2 diabetesa nd theìnsuli.,."rirtu.r." -- syndrome(M onti et al.2003)
Real Time PCR Assay optimization for allelic discrimination of Glu298Asp Polymorphism in the Endothelian Constitutive Nitric Oxide Synthase Gene
BRACALE, Renata;
2005-01-01
Abstract
Nitric oxide (NO) is synthesizefdr om L-arsinine by a family of NO synthase( NOS) irofor.i. -Constitutivelye xpresseNd OS isoformse, ndothelial NOS (eNOS) and neuronal NOS (nNOS), are likely the major contributors ro whole-bodf NO production. Many studies have strongly associated polymorphismso f the eNOS gene. it"h irr..""s"d risk of hypertensionc, ardiovasculadr isease, coronary spastic angina, myocardial infarction, and stroke, but the results are not always con.l.,sirre (l73ng and !7ang 2000). In parricular,V orni-ro et al. (1998) identified a Glu)9gAsp varianr i., 1"o., 7 of the eNOS gene that was more frequent in patientsw ith coronarys pasmb, ut in studieso f an etoerlyp opulationi n Australia,L iyou et al. (199g) could find no associariono f this variant with coronarya rteryd iseaseR. ecently,v ariouse NOS polymorphismsh ave beenr eportedt o be associated with type 2 diabetesa nd theìnsuli.,."rirtu.r." -- syndrome(M onti et al.2003)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
