Interaction of the Hereditary and Environmental Factors in the Psychiatric Disorders associated with Suicidal Behaviour

Data from clinical, twin and adoption studies suggest that genetic factors may play a role as a distal risk factor in suicidal behaviour. The serotonin transporter gene, as a model for studies examining interaction between genes and environment, is discussed. Studies that report interaction between the serotonin transporter and stressful life events, in relation to the development of depression in both adults and adolescents and in relationship to suicidal behaviour, are reviewed. Relevant interaction studies in primates are also discussed.