Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common liver disease in pediatrics. NAFLD is a chronic condition that predisposes to the development of cirrhosis and hepatocellular carcinoma. There is a strong link between NAFLD and type 2 diabetes in adults and adolescents, while some studies suggest that subjects with type 1 diabetes might be protected against the development of NAFLD. In this chapter, we review the pathophysiology and the clinical characteristics of NAFLD in pediatric groups as well as the current treatments being tested.
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