A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine: (>3.77 nmol/mL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29-6.35; P =.01; median permanence time in stage A2, 17 vs. 30.5 months; P =.03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and beta(2)-microglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, >31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters).
Pseudouridine and 1-Ribosylpyridin-4-one-3Carboxamide (PCNR) serum concentrations in HIV-1 infected patients are indipendent predictors for AIDS progression
INTRIERI, Mariano;CALCAGNO, Giuseppe;ZARRILLI, Federica;
1996-01-01
Abstract
A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. Serum concentrations of pseudouridine: (>3.77 nmol/mL) predicted progression to AIDS in CDC stage A2 HIV-infected patients much better than did other widely used parameters (hazard ratio, 2.7; 95% confidence interval, 1.29-6.35; P =.01; median permanence time in stage A2, 17 vs. 30.5 months; P =.03). Serum concentrations of 1-ribosylpyridin-4-one-3-carboxamide (PCNR) and beta(2)-microglobulin and the CD4:CD8 cell ratio, in decreasing order and used in combination, differentiated the overall survival time probability of AIDS patients; PCNR was the best and a new independent predictor (overall survival time, >31 months, no positive parameters; 19.3 months, one positive parameter; and 5.5 months, two positive parameters).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
