"Hollow nanocapsules made of polyelectrolytes, extensively useful for biomedical and biotechnological. applications, are produced with a simple Layer-by-Layer approach using liposomes as template. The. biocompatible polymers, alginate and chitosan, are alternatively adsorbed onto liposomes allowing the. achievement of small size hollow nanocapsules with an average diameter of 280 nm. Hollow. nanocapsules, positively as well as negatively charged, depending on the number of layers, can be. produced in a reproducible way. The produced nanocapsules are demonstrated to be sensitive to pH. changes of the environment because of the behaviour of the polyelectrolytes composing the multishell. walls; in fact they exhibit major variations in size depending on the bulk solution pH. Measurements of. dynamic light scattering (DLS) and of z-potentials as well as SEM observations demonstrate. a correlation between the pH and the shrinking\/swelling of the nanocapsules. While nanocapsules. having chitosan as outer layer are stable only at acidic pH, nanocapsules having alginate as outer layer. remain stable at all the pHs used in this study (pH 4.6 to 8). The pH-optimum for the shrinking event is. in the acidic range. The role of both the polymers in the shrinking\/swelling event is demonstrated by. comparing nanocapsule populations with alginate (7 layers) or chitosan (8 layers) as the outer layer."
|Digital Object Identifier (DOI):||10.1039/c2sm07388a|
|Codice identificativo ISI:||000302030200016|
|Codice identificativo Scopus:||2-s2.0-84859308207|
|Appare nelle tipologie:||1.1 Articolo in rivista|