Abstract—A phytochemical analysis of Aster sedifolius has led to the isolation of three novel triterpenoid saponins, based on an oleane-type skeleton and named astersedifolioside A (1), B (2) and C (3). On the basis of chemical, and 2D NMR and mass spectrometry data, the structures of the new compounds were elucidated as 3-O-[a-L-rhamnopyranosyl (1!2)-b-D-glucopyranosyl] echinocystic acid 28-[O-a-L-rhamnopyranosyl (1!2)-a-L-arabinopyranoside] (1), 3-O-[a-L-rhamnopyranosyl (1!2)-b-D-glucopyranosyl] echinocystic acid 28-[O-b-D-xylopyranosyl (1!4)-O-a-L-rhamnopyranosyl (1!2)-a-L-arabinopyranoside] (2) and 3-O-[a-Lrhamnopyranosyl (1!2)-b-D-glucopyranosyl (1!2)-b-D-glucopyranosyl] echinocystic acid 28-[O-b-D-xylopyranosyl (1!4)-O-a- L-rhamnopyranosyl (1!2)-a-L-arabinopyranoside] (3). The isolated compounds showed antiproliferative effect in KiMol, a transformed thyroid cell line. 2004 Published by Elsevier Ltd.

Astersedifolioside A-C, three new oleane-type saponins with antiproliferative activity.

IORIZZI, Maria;
2004-01-01

Abstract

Abstract—A phytochemical analysis of Aster sedifolius has led to the isolation of three novel triterpenoid saponins, based on an oleane-type skeleton and named astersedifolioside A (1), B (2) and C (3). On the basis of chemical, and 2D NMR and mass spectrometry data, the structures of the new compounds were elucidated as 3-O-[a-L-rhamnopyranosyl (1!2)-b-D-glucopyranosyl] echinocystic acid 28-[O-a-L-rhamnopyranosyl (1!2)-a-L-arabinopyranoside] (1), 3-O-[a-L-rhamnopyranosyl (1!2)-b-D-glucopyranosyl] echinocystic acid 28-[O-b-D-xylopyranosyl (1!4)-O-a-L-rhamnopyranosyl (1!2)-a-L-arabinopyranoside] (2) and 3-O-[a-Lrhamnopyranosyl (1!2)-b-D-glucopyranosyl (1!2)-b-D-glucopyranosyl] echinocystic acid 28-[O-b-D-xylopyranosyl (1!4)-O-a- L-rhamnopyranosyl (1!2)-a-L-arabinopyranoside] (3). The isolated compounds showed antiproliferative effect in KiMol, a transformed thyroid cell line. 2004 Published by Elsevier Ltd.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11695/1309
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